Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2
Identifieur interne : 000151 ( France/Analysis ); précédent : 000150; suivant : 000152Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2
Auteurs : Sophie Blein [France] ; Laure Barjhoux [France] ; Francesca Damiola [France] ; Marie-Gabrielle Dondon [France] ; Séverine Eon-Marchais [France] ; Morgane Marcou [France] ; Olivier Caron [France] ; Alain Lortholary [France] ; Bruno Buecher [France] ; Philippe Vennin [France] ; Pascaline Berthet [France] ; Catherine Noguès [France] ; Christine Lasset [France] ; Marion Gauthier-Villars [France] ; Sylvie Mazoyer [France] ; Dominique Stoppa-Lyonnet [France] ; Nadine Andrieu [France] ; Gilles Thomas [France] ; Olga M. Sinilnikova [France] ; David G. Cox [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Breast Cancer is a complex multifactorial disease for which high-penetrance mutations have been identified. Approaches used to date have identified genomic features explaining about 50% of breast cancer heritability. A number of low- to medium penetrance alleles (per-allele odds ratio < 1.5 and 4.0, respectively) have been identified, suggesting that the remaining heritability is likely to be explained by the cumulative effect of such alleles and/or by rare high-penetrance alleles. Relatively few studies have specifically explored the mitochondrial genome for variants potentially implicated in breast cancer risk. For these reasons, we propose an exploration of the variability of the mitochondrial genome in individuals diagnosed with breast cancer, having a positive breast cancer family history but testing negative for
Url:
DOI: 10.1371/journal.pone.0136192
PubMed: 26406445
PubMed Central: 4583250
Affiliations:
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PMC:4583250Le document en format XML
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type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Mines ParisTech, Fontainebleau, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Mines ParisTech, Fontainebleau</wicri:regionArea><placeName><settlement type="city">Fontainebleau</settlement></placeName></affiliation></author><author><name sortKey="Eon Marchais, Severine" sort="Eon Marchais, Severine" uniqKey="Eon Marchais S" first="Séverine" last="Eon-Marchais">Séverine Eon-Marchais</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Inserm, U900, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U900, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Curie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Mines ParisTech, Fontainebleau, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Mines ParisTech, Fontainebleau</wicri:regionArea><placeName><settlement type="city">Fontainebleau</settlement></placeName></affiliation></author><author><name sortKey="Marcou, Morgane" sort="Marcou, Morgane" uniqKey="Marcou M" first="Morgane" last="Marcou">Morgane Marcou</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Inserm, U900, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U900, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Lortholary, Alain" sort="Lortholary, Alain" uniqKey="Lortholary A" first="Alain" last="Lortholary">Alain Lortholary</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Centre Catherine de Sienne, Nantes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Catherine de Sienne, Nantes</wicri:regionArea><placeName><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Institut Curie, Department of Tumour Biology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Department of Tumour Biology, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vennin, Philippe" sort="Vennin, Philippe" uniqKey="Vennin P" first="Philippe" last="Vennin">Philippe Vennin</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Département de Cancérologie sénologique, CLCC Oscar Lambret, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Cancérologie sénologique, CLCC Oscar Lambret, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Centre François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Oncogénétique Clinique, Hôpital René Huguenin/Institut Curie, Saint-Cloud</wicri:regionArea><wicri:noRegion>Saint-Cloud</wicri:noRegion><wicri:noRegion>Saint-Cloud</wicri:noRegion></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Université Lyon 1, CNRS UMR5558, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lyon 1, CNRS UMR5558, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Institut Curie, INSERM U830, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, INSERM U830, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff014"><addr-line>Université Paris Descartes, Sorbonne Paris Cité, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité</wicri:regionArea><wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion><orgName type="university">Université Paris Descartes</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Andrieu, Nadine" sort="Andrieu, Nadine" uniqKey="Andrieu N" first="Nadine" last="Andrieu">Nadine Andrieu</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Inserm, U900, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U900, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Curie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Mines ParisTech, Fontainebleau, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Mines ParisTech, Fontainebleau</wicri:regionArea><placeName><settlement type="city">Fontainebleau</settlement></placeName></affiliation></author><author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Université Lyon 1, INCa-Synergie, Centre Léon Bérard, 28 rue Laennec, Lyon Cedex 08, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lyon 1, INCa-Synergie, Centre Léon Bérard, 28 rue Laennec, Lyon Cedex 08</wicri:regionArea><wicri:noRegion>Lyon Cedex 08</wicri:noRegion><wicri:noRegion>Lyon Cedex 08</wicri:noRegion></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff016"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Breast Cancer is a complex multifactorial disease for which high-penetrance mutations have been identified. Approaches used to date have identified genomic features explaining about 50% of breast cancer heritability. A number of low- to medium penetrance alleles (per-allele odds ratio < 1.5 and 4.0, respectively) have been identified, suggesting that the remaining heritability is likely to be explained by the cumulative effect of such alleles and/or by rare high-penetrance alleles. Relatively few studies have specifically explored the mitochondrial genome for variants potentially implicated in breast cancer risk. For these reasons, we propose an exploration of the variability of the mitochondrial genome in individuals diagnosed with breast cancer, having a positive breast cancer family history but testing negative for <italic>BRCA1</italic>/<italic>2</italic> pathogenic mutations. We sequenced the mitochondrial genome of 436 index breast cancer cases from the GENESIS study. As expected, no pathogenic genomic pattern common to the 436 women included in our study was observed. The mitochondrial genes <italic>MT-ATP6</italic> and <italic>MT-CYB</italic> were observed to carry the highest number of variants in the study. The proteins encoded by these genes are involved in the structure of the mitochondrial respiration chain, and variants in these genes may impact reactive oxygen species production contributing to carcinogenesis. More functional and epidemiological studies are needed to further investigate to what extent variants identified may influence familial breast cancer risk.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalloo, F" uniqKey="Lalloo F">F Lalloo</name></author><author><name sortKey="Evans, Dg" uniqKey="Evans D">DG Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newman, B" uniqKey="Newman B">B 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De Baulny</name></author><author><name sortKey="Laforet, P" uniqKey="Laforet P">P Laforet</name></author><author><name sortKey="Jardel, C" uniqKey="Jardel C">C Jardel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picardi, E" uniqKey="Picardi E">E Picardi</name></author><author><name sortKey="Pesole, G" uniqKey="Pesole G">G Pesole</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bragg, Lm" uniqKey="Bragg L">LM Bragg</name></author><author><name sortKey="Stone, G" uniqKey="Stone G">G Stone</name></author><author><name sortKey="Butler, Mk" uniqKey="Butler M">MK Butler</name></author><author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name></author><author><name sortKey="Tyson, Gw" uniqKey="Tyson G">GW Tyson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quail, M" uniqKey="Quail M">M Quail</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author><author><name sortKey="Coupland, P" uniqKey="Coupland P">P Coupland</name></author><author><name sortKey="Otto, Td" uniqKey="Otto T">TD Otto</name></author><author><name sortKey="Harris, Sr" uniqKey="Harris S">SR Harris</name></author><author><name sortKey="Connor, Tr" uniqKey="Connor T">TR Connor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loman, Nj" uniqKey="Loman N">NJ Loman</name></author><author><name sortKey="Misra, Rv" uniqKey="Misra R">RV Misra</name></author><author><name sortKey="Dallman, Tj" uniqKey="Dallman T">TJ Dallman</name></author><author><name sortKey="Constantinidou, C" uniqKey="Constantinidou C">C Constantinidou</name></author><author><name sortKey="Gharbia, Se" uniqKey="Gharbia S">SE Gharbia</name></author><author><name sortKey="Wain, J" uniqKey="Wain J">J Wain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parson, W" uniqKey="Parson W">W Parson</name></author><author><name sortKey="Strobi, C" uniqKey="Strobi C">C Strobi</name></author><author><name sortKey="Huber, G" uniqKey="Huber G">G Huber</name></author><author><name sortKey="Zimmermann, B" uniqKey="Zimmermann B">B Zimmermann</name></author><author><name sortKey="Gomes, Sm" uniqKey="Gomes S">SM Gomes</name></author><author><name sortKey="Souto, L" uniqKey="Souto L">L Souto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lynch, H" uniqKey="Lynch H">H Lynch</name></author><author><name sortKey="Wen, H" uniqKey="Wen H">H Wen</name></author><author><name sortKey="Kim, Yc" uniqKey="Kim Y">YC Kim</name></author><author><name sortKey="Snyder, C" uniqKey="Snyder C">C Snyder</name></author><author><name sortKey="Kinarsky, Y" uniqKey="Kinarsky Y">Y Kinarsky</name></author><author><name sortKey="Chen, Px" uniqKey="Chen P">PX Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tommasi, S" uniqKey="Tommasi S">S Tommasi</name></author><author><name sortKey="Favia, P" uniqKey="Favia P">P Favia</name></author><author><name sortKey="Weigl, S" uniqKey="Weigl S">S Weigl</name></author><author><name sortKey="Bianco, A" uniqKey="Bianco A">A Bianco</name></author><author><name sortKey="Pilato, B" uniqKey="Pilato B">B Pilato</name></author><author><name sortKey="Russo, L" uniqKey="Russo L">L Russo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snape, K" uniqKey="Snape K">K Snape</name></author><author><name sortKey="Ruark, E" uniqKey="Ruark E">E Ruark</name></author><author><name sortKey="Tarpey, P" uniqKey="Tarpey P">P Tarpey</name></author><author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name></author><author><name sortKey="Turnbull, C" uniqKey="Turnbull C">C Turnbull</name></author><author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Er" uniqKey="Thompson E">ER Thompson</name></author><author><name sortKey="Doyle, Ma" uniqKey="Doyle M">MA Doyle</name></author><author><name sortKey="Ryland, Gl" uniqKey="Ryland G">GL Ryland</name></author><author><name sortKey="Rowley, Sm" uniqKey="Rowley S">SM Rowley</name></author><author><name sortKey="Choong, Dy" uniqKey="Choong D">DY Choong</name></author><author><name sortKey="Tothill, Rw" uniqKey="Tothill R">RW Tothill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name></author><author><name sortKey="Park, Dj" uniqKey="Park D">DJ Park</name></author><author><name sortKey="Nguyen Dumont, T" uniqKey="Nguyen Dumont T">T Nguyen-Dumont</name></author><author><name sortKey="Campbell, I" uniqKey="Campbell I">I Campbell</name></author><author><name sortKey="Thompson, E" uniqKey="Thompson E">E Thompson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Caen</li><li>Fontainebleau</li><li>Lille</li><li>Lyon</li><li>Nantes</li><li>Paris</li></settlement><orgName><li>Université Paris Descartes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Blein, Sophie" sort="Blein, Sophie" uniqKey="Blein S" first="Sophie" last="Blein">Sophie Blein</name></noRegion><name sortKey="Andrieu, Nadine" sort="Andrieu, Nadine" uniqKey="Andrieu N" first="Nadine" last="Andrieu">Nadine Andrieu</name><name sortKey="Andrieu, Nadine" sort="Andrieu, Nadine" uniqKey="Andrieu N" first="Nadine" last="Andrieu">Nadine Andrieu</name><name sortKey="Andrieu, Nadine" sort="Andrieu, Nadine" uniqKey="Andrieu N" first="Nadine" last="Andrieu">Nadine Andrieu</name><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><name sortKey="Dondon, Marie Gabrielle" sort="Dondon, Marie Gabrielle" uniqKey="Dondon M" first="Marie-Gabrielle" last="Dondon">Marie-Gabrielle Dondon</name><name sortKey="Dondon, Marie Gabrielle" sort="Dondon, Marie Gabrielle" uniqKey="Dondon M" first="Marie-Gabrielle" last="Dondon">Marie-Gabrielle Dondon</name><name sortKey="Dondon, Marie Gabrielle" sort="Dondon, Marie Gabrielle" uniqKey="Dondon M" first="Marie-Gabrielle" last="Dondon">Marie-Gabrielle Dondon</name><name sortKey="Eon Marchais, Severine" sort="Eon Marchais, Severine" uniqKey="Eon Marchais S" first="Séverine" last="Eon-Marchais">Séverine Eon-Marchais</name><name sortKey="Eon Marchais, Severine" sort="Eon Marchais, Severine" uniqKey="Eon Marchais S" first="Séverine" last="Eon-Marchais">Séverine Eon-Marchais</name><name sortKey="Eon Marchais, Severine" sort="Eon Marchais, Severine" uniqKey="Eon Marchais S" first="Séverine" last="Eon-Marchais">Séverine Eon-Marchais</name><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><name sortKey="Lortholary, Alain" sort="Lortholary, Alain" uniqKey="Lortholary A" first="Alain" last="Lortholary">Alain Lortholary</name><name sortKey="Marcou, Morgane" sort="Marcou, Morgane" uniqKey="Marcou M" first="Morgane" last="Marcou">Morgane Marcou</name><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><name sortKey="Vennin, Philippe" sort="Vennin, Philippe" uniqKey="Vennin P" first="Philippe" last="Vennin">Philippe Vennin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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